انتشار مقاله در مجله Behavioural Brain Research با حمایت قطب عصب روانشناسی شناختی

انتشار مقاله

Autistic-Like Behaviours and Associated Brain Structural Plasticity are Modulated by Oxytocin in Maternally Separated Rats

Monireh Mansouri, Hamidreza Pouretemad, Mehrdad Roghani, Gregers Wegener, Maryam Ardalan

Abstract
Background: Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain abnormalities, including alteration of oxytocin receptors in the brain. Recently, early life adverse experiences, such as maternal separation (MS), have been shown to constitute risk factors for ASD in preclinical studies. Therefore, the main aims of the current study were to i) explore the association between onset of autistic-like behaviours and molecular/structural changes in the brain following MS, and ii) evaluate the possible beneficial effects of oxytocin treatment on the same parameters.

Method and Material: Male rats were exposed to the maternal separation from post-natal day (PND) 1 to PND14. After weaning, daily injections of oxytocin (1mg/kg, ip) were administered (PND22-30), followed by examination of autism-related behaviours at adolescence (PND 42-50). Brain structural plasticity was examined using stereological methods, and the plasma level of brain derived neurotrophic factor (BDNF) was analysed using ELISA.

Results: We found that maternal separation induced autistic-like behaviours, which was associated with increase in the hippocampal CA1 stratum radiatum (CA1.SR) volume. In addition, we observed increase in the infralimbic brain region volume and in the number of the pyramidal neurons in the same brain region. Maternal separation significantly increased the plasma BDNF levels. Treatment with oxytocin improved autistic like behaviours, normalized the number of neurons and the volume of the infralimbic region as well as the plasma BDNF level (p<0.05).

Conclusion: Maternal separation induced autistic-like behaviours, brain structural impairment together with plasma BDNF level abnormality, which could be improved by oxytocin treatment.

 


 

انتشار مقاله در مجله Computer with Engineering با حمایت قطب عصب روانشناسی شناختی

انتشار مقاله

An efficient space‑splitting method for simulating brain neurons by neuronal synchronization to control epileptic activity در مجله Engineering with Computers

M. M. Moayeri · A. H. Hadian‑Rasanan · S. Latifi · K. Parand1, · J. A. Rad

Abstract
Controlling synchronization of neural networks in brain activity is an important issue in neurodevelopmental disorders such as epileptic seizures. In this paper, we propose an efficient numerical method to simulate nonlinear spatio-temporal neural dynamic models and their synchronizations. In this study, the generalized Lagrange Jacobi Gauss–Lobatto collocation method combined with Trotter operator splitting technique is employed. This method allows us to decouple the nonlinear partial differential equations of neural network models into independent linear algebraic equations of very small dimensions. Moreover, we examine different test cases to indicate the advantages of the proposed method in accuracy, computational cost, and complexity. It is shown that the computational complexity of the proposed method is much smaller than the complexity of pure spectral method. Finally, A GPU implementation is applied on the two dimensional models to accelerate the time consuming simulations.